abstract：:Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pa...

journal_title：Cancer research

authors： Park EY,Chang E,Lee EJ,Lee HW,Kang HG,Chun KH,Woo YM,Kong HK,Ko JY,Suzuki H,Song E,Park JH

更新日期：2014-12-15 00:00:00

abstract：:The use of targeted therapeutics directed against BRAF(V600)-mutant metastatic melanoma improves progression-free survival in many patients; however, acquired drug resistance remains a major medical challenge. By far, the most common clinical resistance mechanism involves reactivation of the MAPK (RAF/MEK/ERK) pathway...

journal_title：Cancer research

authors： Goetz EM,Ghandi M,Treacy DJ,Wagle N,Garraway LA

更新日期：2014-12-01 00:00:00

abstract：:Studies in animals and humans show that blockade of nerve growth factor (NGF) attenuates both malignant and nonmalignant skeletal pain. While reduction of pain is important, a largely unanswered question is what other benefits NGF blockade might confer in patients with bone cancer. Using a mouse graft model of bone sa...

journal_title：Cancer research

authors： McCaffrey G,Thompson ML,Majuta L,Fealk MN,Chartier S,Longo G,Mantyh PW

更新日期：2014-12-01 00:00:00

abstract：:Although in vivo targeting of tumors using fluorescently labeled probes has greatly gained in importance over the last few years, most of the clinically applied reagents lack tumor cell specificity. Our novel tumor cell-penetrating peptide-based probe (TPP) recognizes an epitope of Hsp70 that is exclusively present on...

journal_title：Cancer research

authors： Stangl S,Varga J,Freysoldt B,Trajkovic-Arsic M,Siveke JT,Greten FR,Ntziachristos V,Multhoff G

更新日期：2014-12-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. On the basis of its histopathology and molecular-genomic changes, ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC xenografts that recapit...

journal_title：Cancer research

authors： Ricci F,Bizzaro F,Cesca M,Guffanti F,Ganzinelli M,Decio A,Ghilardi C,Perego P,Fruscio R,Buda A,Milani R,Ostano P,Chiorino G,Bani MR,Damia G,Giavazzi R

更新日期：2014-12-01 00:00:00

abstract：:Pregnancy, parity, and circulating steroid hormone levels are associated with risk of breast cancer, but little is known about hormone concentrations during pregnancy and subsequent breast cancer risk. We evaluated early pregnancy (<140 days gestation) serum estradiol, estrone, progesterone, and testosterone and breas...

journal_title：Cancer research

authors： Fortner RT,Schock H,Kaaks R,Lehtinen M,Pukkala E,Lakso HÅ,Tanner M,Kallio R,Joensuu H,Grankvist K,Zeleniuch-Jacquotte A,Toniolo P,Lundin E,Surcel HM

更新日期：2014-12-01 00:00:00

abstract：:Although significant advances in radiotherapy have increased its effectiveness in many cancer settings, general strategies to widen the therapeutic window between normal tissue toxicity and malignant tumor destruction would still offer great value. CD47 blockade has been found to confer radioprotection to normal tissu...

journal_title：Cancer research

authors： Soto-Pantoja DR,Terabe M,Ghosh A,Ridnour LA,DeGraff WG,Wink DA,Berzofsky JA,Roberts DD

更新日期：2014-12-01 00:00:00

abstract：:Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. GPx2 silencing...

journal_title：Cancer research

authors： Emmink BL,Laoukili J,Kipp AP,Koster J,Govaert KM,Fatrai S,Verheem A,Steller EJ,Brigelius-Flohé R,Jimenez CR,Borel Rinkes IH,Kranenburg O

更新日期：2014-11-15 00:00:00

abstract：:Extramedullary myelopoiesis occurs commonly in tumor-bearing animals and is known to lead to accumulation of peripheral myeloid-derived suppressor cells (MDSC), which play an important role in immune escape. However, the cellular and molecular mechanisms by which tumors induce extramedullary myelopoiesis are poorly un...

journal_title：Cancer research

authors： Kim EK,Jeon I,Seo H,Park YJ,Song B,Lee KA,Jang Y,Chung Y,Kang CY

更新日期：2014-11-15 00:00:00

abstract：:SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-cycle control, programmed cell death, differentiation, genomic instability, and DNA repair. Inactivation of this class of chromatin remodeling complex has been associated with a variety of malignancies, including lung, ovarian,...

journal_title：Cancer research

authors： Orvis T,Hepperla A,Walter V,Song S,Simon J,Parker J,Wilkerson MD,Desai N,Major MB,Hayes DN,Davis IJ,Weissman B

更新日期：2014-11-15 00:00:00

abstract：:Epidemiologic studies linking high serum iron with cancer risks are limited and inconclusive, despite evidence implicating body iron in human carcinogenesis. A cohort of 309,443 adults in Taiwan who had no history of cancer had serum iron levels tested at the time of recruitment (1997-2008). Initially measured iron le...

journal_title：Cancer research

authors： Wen CP,Lee JH,Tai YP,Wen C,Wu SB,Tsai MK,Hsieh DP,Chiang HC,Hsiung CA,Hsu CY,Wu X

更新日期：2014-11-15 00:00:00

abstract：:Defining tumor stage at diagnosis is a pivotal point for clinical decisions about patient treatment strategies. In this respect, early detection of occult metastasis invisible to current imaging methods would have a major impact on best care and long-term survival. Mathematical models that describe metastatic spreadin...

journal_title：Cancer research

authors： Hartung N,Mollard S,Barbolosi D,Benabdallah A,Chapuisat G,Henry G,Giacometti S,Iliadis A,Ciccolini J,Faivre C,Hubert F

更新日期：2014-11-15 00:00:00

abstract：:Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can lead to the Smad3 l...

journal_title：Cancer research

authors： Bae E,Sato M,Kim RJ,Kwak MK,Naka K,Gim J,Kadota M,Tang B,Flanders KC,Kim TA,Leem SH,Park T,Liu F,Wakefield LM,Kim SJ,Ooshima A

更新日期：2014-11-01 00:00:00

abstract：:SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer. Here, we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits sk...

journal_title：Cancer research

authors： Ming M,Han W,Zhao B,Sundaresan NR,Deng CX,Gupta MP,He YY

更新日期：2014-10-15 00:00:00

abstract：:The discovery of somatic mutations in EGFR and development of EGFR tyrosine kinase inhibitors (TKI) have revolutionized treatment for lung cancer. However, resistance to TKIs emerges in almost all patients and currently no effective treatment is available. Here, we show that β-catenin is essential for development of E...

journal_title：Cancer research

authors： Nakayama S,Sng N,Carretero J,Welner R,Hayashi Y,Yamamoto M,Tan AJ,Yamaguchi N,Yasuda H,Li D,Soejima K,Soo RA,Costa DB,Wong KK,Kobayashi SS

更新日期：2014-10-15 00:00:00

abstract：:Activation of c-MYC is an oncogenic hallmark of many cancers, including liver cancer, and is associated with a variety of adverse prognostic characteristics. Despite a causative role during malignant transformation and progression in hepatocarcinogenesis, consequences of c-MYC activation for the biology of hepatic can...

journal_title：Cancer research

authors： Akita H,Marquardt JU,Durkin ME,Kitade M,Seo D,Conner EA,Andersen JB,Factor VM,Thorgeirsson SS

更新日期：2014-10-15 00:00:00

abstract：:Tubulysins are highly toxic tubulin-targeting agents with a narrow therapeutic window that are interesting for application in antibody-drug conjugates (ADC). For full control over drug-antibody ratio (DAR) and the effect thereof on pharmacokinetics and tumor targeting, a dual-labeling approach was developed, wherein t...

journal_title：Cancer research

authors： Cohen R,Vugts DJ,Visser GW,Stigter-van Walsum M,Bolijn M,Spiga M,Lazzari P,Shankar S,Sani M,Zanda M,van Dongen GA

更新日期：2014-10-15 00:00:00

abstract：:High-grade gliomas are characterized by exuberant vascularization, diffuse invasion, and significant chemoresistance, resulting in a recurrent phenotype that makes them impossible to eradicate in the long term. Targeting protumoral signals in the glioma microenvironment could have significant impact against tumor cell...

journal_title：Cancer research

authors： Nandhu MS,Hu B,Cole SE,Erdreich-Epstein A,Rodriguez-Gil DJ,Viapiano MS

更新日期：2014-10-01 00:00:00

abstract：:The p21-activated Ser/Thr kinase 1 (PAK1) kinase has an essential role in tumorigenesis and cell survival in many cancers, but its regulation is not fully understood. In this study, we showed that in response to irradiation of lung cancer cells, PAK1 was upregulated, tyrosine phosphorylated, and translocated to the nu...

journal_title：Cancer research

authors： Kim E,Youn H,Kwon T,Son B,Kang J,Yang HJ,Seong KM,Kim W,Youn B

更新日期：2014-10-01 00:00:00

abstract：:Natural killer (NK) cells safeguard against early tumor formation by destroying transformed target cells in a process referred to as NK immune surveillance. However, the immune escape mechanisms used by malignant brain tumors to subvert this innate type of immune surveillance remain unclear. Here we show that malignan...

journal_title：Cancer research

authors： Baker GJ,Chockley P,Yadav VN,Doherty R,Ritt M,Sivaramakrishnan S,Castro MG,Lowenstein PR

更新日期：2014-09-15 00:00:00

abstract：:Elevated levels of TGFβ are a negative prognostic indicator for patients diagnosed with pancreatic cancer; as a result, the TGFβ pathway is an attractive target for therapy. However, clinical application of pharmacologic inhibition of TGFβ remains challenging because TGFβ has tumor suppressor functions in many epithel...

journal_title：Cancer research

authors： Ostapoff KT,Cenik BK,Wang M,Ye R,Xu X,Nugent D,Hagopian MM,Topalovski M,Rivera LB,Carroll KD,Brekken RA

更新日期：2014-09-15 00:00:00

abstract：:Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here, we identify Runx2 as a new regulator of epithelial cell fate in mammary gland development and breast cancer. Runx2 is expressed in the epithelium of pregnant mice in a strict temporally and hormonally regula...

journal_title：Cancer research

authors： Owens TW,Rogers RL,Best S,Ledger A,Mooney AM,Ferguson A,Shore P,Swarbrick A,Ormandy CJ,Simpson PT,Carroll JS,Visvader J,Naylor MJ

更新日期：2014-09-15 00:00:00

abstract：:Inflammatory stimuli clearly contribute to lung cancer development and progression, but the underlying pathogenic mechanisms are not fully understood. We found that the proinflammatory cytokine IL-1β is dramatically elevated in the serum of patients with non-small cell lung cancer (NSCLC). In vitro studies showed that...

journal_title：Cancer research

authors： Wang L,Zhang LF,Wu J,Xu SJ,Xu YY,Li D,Lou JT,Liu MF

更新日期：2014-09-01 00:00:00

abstract：:Methods to visualize metastasis exist, but additional tools to better define the biologic and physical processes underlying invasion and intravasation are still needed. One difficulty in studying metastasis stems from the complexity of the interface between the tumor microenvironment and the vascular system. Here, we ...

journal_title：Cancer research

authors： Wong AD,Searson PC

更新日期：2014-09-01 00:00:00

abstract：:Whole-genome sequencing studies have recently identified a quarter of cases of the rare childhood brainstem tumor diffuse intrinsic pontine glioma to harbor somatic mutations in ACVR1. This gene encodes the type I bone morphogenic protein receptor ALK2, with the residues affected identical to those that, when mutated ...

journal_title：Cancer research

authors： Taylor KR,Vinci M,Bullock AN,Jones C

更新日期：2014-09-01 00:00:00

abstract：:The issue of resistance to targeted drug therapy is of pressing concern, as it constitutes a major barrier to progress in managing cancer. One important aspect is the role of stochasticity in determining the nature of the patient response. We examine two particular experiments. The first measured the maximal response ...

journal_title：Cancer research

authors： Kessler DA,Austin RH,Levine H

更新日期：2014-09-01 00:00:00

abstract：:Pentraxin-3 (PTX3) is a member of the pentraxin family of innate immune regulators, which includes C-reactive protein (CRP). PTX3 has been implicated in angiogenesis, proliferation, and immune escape in cancer. In the present study, we evaluated PTX3 tissue expression and serum concentration as a biomarker to discrimi...

journal_title：Cancer research

authors： Stallone G,Cormio L,Netti GS,Infante B,Selvaggio O,Fino GD,Ranieri E,Bruno F,Prattichizzo C,Sanguedolce F,Tortorella S,Bufo P,Grandaliano G,Carrieri G

更新日期：2014-08-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) was thought historically to arise from hepatocytes, but gene expression studies have suggested that it can also arise from fetal progenitor cells or their adult progenitor progeny. Here, we report the identification of a unique population of fetal liver progenitor cells in mice that can ...

journal_title：Cancer research

authors： Mokkapati S,Niopek K,Huang L,Cunniff KJ,Ruteshouser EC,deCaestecker M,Finegold MJ,Huff V

更新日期：2014-08-15 00:00:00

abstract：:The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, a major barrier imposed on tumor cells early in tumorigenesis. MYC is a key factor in suppression of RAS/BRAF(V600E)-induced senescence in vitro. However, it is still unclear whether MYC has the same rol...

journal_title：Cancer research

authors： Tabor V,Bocci M,Alikhani N,Kuiper R,Larsson LG

更新日期：2014-08-15 00:00:00

abstract：:ERBB3/HER3 expression and signaling are upregulated in mutant BRAF melanoma as an adaptive, prosurvival response to FDA-approved RAF inhibitors. Because compensatory ERBB3 signaling counteracts the effects of RAF inhibitors, cotargeting ERBB3 may increase the efficacy of RAF inhibitors in mutant BRAF models of melanom...

journal_title：Cancer research

authors： Kugel CH 3rd,Hartsough EJ,Davies MA,Setiady YY,Aplin AE

更新日期：2014-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is characterized by a pathogenic vasculature that drives aggressive local invasion. Recent work suggests that GBM cells recruit bone marrow-derived progenitor cells (BMDC) to facilitate recurrence after radiotherapy, but how this may be achieved is unclear. In this study, we established t...

journal_title：Cancer research

authors： Burrell K,Singh S,Jalali S,Hill RP,Zadeh G

更新日期：2014-07-15 00:00:00

abstract：:Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed in cancer where it may impact cell proliferation. In t...

journal_title：Cancer research

authors： Gopinathan L,Tan SL,Padmakumar VC,Coppola V,Tessarollo L,Kaldis P

更新日期：2014-07-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is an aggressive clinical subtype accounting for up to 20% of all breast cancers, but its malignant determinants remain largely undefined. Here, we show that in TNBC the overexpression of Fra-1, a component of the transcription factor AP-1, offers prognostic potential. Fra-1 deplet...

journal_title：Cancer research

authors： Zhao C,Qiao Y,Jonsson P,Wang J,Xu L,Rouhi P,Sinha I,Cao Y,Williams C,Dahlman-Wright K

更新日期：2014-07-15 00:00:00

abstract：:Despite some advances, pancreatic ductal adenocarcinoma (PDAC) remains generally refractory to current treatments. Desmoplastic stroma, a consistent hallmark of PDAC, has emerged as a major source of therapeutic resistance and thus potentially promising targets for improved treatment. The glycan-binding protein galect...

journal_title：Cancer research

authors： Martínez-Bosch N,Fernández-Barrena MG,Moreno M,Ortiz-Zapater E,Munné-Collado J,Iglesias M,André S,Gabius HJ,Hwang RF,Poirier F,Navas C,Guerra C,Fernández-Zapico ME,Navarro P

更新日期：2014-07-01 00:00:00

abstract：:Breast cancer stem-like cells (BCSC) have been implicated in tumor growth, metastasis, drug resistance, and relapse but druggable targets in appropriate subsets of this cell population have yet to be identified. Here we identify a fundamental role for the prolyl isomerase Pin1 in driving BCSC expansion, invasiveness, ...

journal_title：Cancer research

authors： Luo ML,Gong C,Chen CH,Lee DY,Hu H,Huang P,Yao Y,Guo W,Reinhardt F,Wulf G,Lieberman J,Zhou XZ,Song E,Lu KP

更新日期：2014-07-01 00:00:00

abstract：:PRL-3, an oncogenic dual-specificity phosphatase, is overexpressed in 50% of acute myelogenous leukemia (AML) and associated with poor survival. We found that stable expression of PRL-3 confers cytokine independence and growth advantage of AML cells. However, how PRL-3 mediates these functions in AML is not known. To ...

journal_title：Cancer research

authors： Chong PS,Zhou J,Cheong LL,Liu SC,Qian J,Guo T,Sze SK,Zeng Q,Chng WJ

更新日期：2014-06-01 00:00:00

abstract：:Taxane antineoplastic agents are extensively taken up into hepatocytes by OATP1B-type transporters before metabolism and excretion. Because the biodistributional properties imposed upon these agents by different solubilizers drive clinically important pharmacodynamic endpoints, we tested the hypothesis that the in vit...

journal_title：Cancer research

authors： Nieuweboer AJ,Hu S,Gui C,Hagenbuch B,Ghobadi Moghaddam-Helmantel IM,Gibson AA,de Bruijn P,Mathijssen RH,Sparreboom A

更新日期：2014-06-01 00:00:00

abstract：:The nodal regulatory properties of microRNAs (miRNA) in metastatic cancer may offer new targets for therapeutic control. Here, we report that upregulation of miR-483-5p is correlated with the progression of human lung adenocarcinoma. miR-483-5p promotes the epithelial-mesenchymal transition (EMT) accompanied by invasi...

journal_title：Cancer research

authors： Song Q,Xu Y,Yang C,Chen Z,Jia C,Chen J,Zhang Y,Lai P,Fan X,Zhou X,Lin J,Li M,Ma W,Luo S,Bai X

更新日期：2014-06-01 00:00:00

abstract：:Resistance to anticancer therapeutics greatly affects the phenotypic and functional properties of tumor cells, but how chemoresistance contributes to the tumorigenic activities of cancer stem-like cells remains unclear. In this study, we found that a characteristic of cancer stem-like cells from chemoresistant tumors ...

journal_title：Cancer research

authors： Yamashina T,Baghdadi M,Yoneda A,Kinoshita I,Suzu S,Dosaka-Akita H,Jinushi M

更新日期：2014-05-15 00:00:00

abstract：:The DNA damage response kinase ATR and its effector kinase CHEK1 are required for cancer cells to survive oncogene-induced replication stress. ATR inhibitors exhibit synthetic lethal interactions, with deficiencies in the DNA damage response enzymes ATM and XRCC1 and with overexpression of the cell cycle kinase cyclin...

journal_title：Cancer research

authors： Mohni KN,Kavanaugh GM,Cortez D

更新日期：2014-05-15 00:00:00